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Causes of infertility include genetic abnormalities, certain acute and chronic diseases, exposure to certain environmental toxins, smoking, and excessive alcohol use (2). A Physical Map of the Human Y Chromosome. (PDF, 160 KB) Nature, 2001. About 92 out of 100 couples who are trying to get pregnant do so within two years.[citation needed] Women become less fertile as they get older. Microsurgery in Pediatric Urology. (PDF, 13 MB) The National Foundation, 1977. Associated conditions[edit] For most women, alteration of menstrual periods is the principal indication of chronic anovulation. There may be testicular malformations, hormone imbalance, or blockage of the man's duct system.

Damaged Sperm Ducts: Seven percent of infertile men cannot transport sperm from their testicles to out of their penis.  This pathway may be blocked by a number of conditions: · A genetic or developmental mistake may block or cause the absence of one or both tubes (which   transport the sperm from the testes to the penis). · Scarring from tuberculosis or some STDs may block the epididymis or tubes. · An elective or accidental vasectomy may interrupt tube continuity. Heavy alcohol use (more than four to five drinks a day). Blood tests Depending on the individual couple's situation, various blood tests on either the female or the male may be needed. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Castration of the affected testis may allow the other testis to regain its ability to produce sperm, but the prognosis is guarded.

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A rapid slide agglutination test (RSAT) kit to detect serum antibodies is commercially available. Bensdorp AJ, Cohlen BJ, Heineman MJ, Vandekerckhove P. Clinical diagnostic testing for the cytogenetic and molecular causes of male infertility: the Mayo Clinic experience. Sperm can survive inside the female for up to 5 days, while an egg can be fertilized for up to 1 day after ovulation. These may be purchased over the counter and allow couples to predict the most fertile days in the cycle.

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Chemotherapy: Some chemotherapy drugs can result in ovarian failure. Conventional In-vitro Fertilization vs Intracytoplasmic Sperm Injection for Patients Requiring Microsurgical Sperm Aspiration. (PDF, 3 MB) Human Reproduction, 1994. Review Questions The answers can be found below the references.

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There are several requirements for male fertility. These include: Reduced hemorrhaging, which reduces the chance of needing a blood transfusion.[11][12] Smaller incision, which reduces pain and shortens recovery time, as well as resulting in less post-operative scarring.[12][13][14] Less pain, leading to less pain medication needed.[15][14] Although procedure times are usually slightly longer, hospital stay is less, and often with a same day discharge which leads to a faster return to everyday living.[13][16] Reduced exposure of internal organs to possible external contaminants thereby reduced risk of acquiring infections.[6] There are more indications for laparoscopic surgery in gastrointestinal emergencies as the field develops.[17] Although laparoscopy in adult age group is widely accepted, its advantages in pediatric age group is questioned.[18][19] Benefits of laparoscopy appears to recede with younger age. Men with Infertility Caused by AZFc Deletion can Produce Sons by Intracytoplasmic Sperm Injection, but are Likely to Transmit the Deletion and Infertility. (PDF, 102 KB) Human Reproduction, 1999. View Media Gallery Sperm next enter the vas deferens, a 30- to 35-cm muscular conduit of Wolffian duct origin. However, in our modern era, women are delaying child birth until their thirties and forties, which has lead to the discovery of the adverse effect of advanced maternal age on egg function. However, further testing may include: A general physical exam by a urologist. Fertilizing Capacity of Epididymal and Testicular Sperm with ICSI. (PDF, 5 MB) Frontiers in Endocrinology, 1995. In ZIFT, your doctor places the fertilized eggs -- at this stage called zygotes -- into your fallopian tubes within 24 hours. This is called luteinised unruptured follicle syndrome (LUFS). At this point, psychological consultation and support should be provided [44]. There is still some controversy about their existence, but if the discoveries are true, this could mean a new treatment for infertility.[71] Stem cell therapy is really new, and everything is still under investigation. Although the sperm count may be slightly decreased by an intercourse frequency of once per day or once every other day, the motility and number of sperm in the healthy male would be sufficient to achieve pregnancy. The use of Epididymal and Testicular Sperm for ICSI. (PDF, 1 MB) From IX World Congress on In Vitro Fertilization and Alternated Assisted Reproduction, 1995.