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Low sperm mobility (motility): The sperm cannot "swim" as well as they should to reach the egg. Ovarian Transplantation in a Series of Monozygotic Twins Discordant for Ovarian Failure. (PDF, 188 KB) The New England Journal of Medicine, 2007.

Metformin (Glucophage): If Clomifene is not effective, metformin may help women with PCOS, especially when linked to insulin resistance. Certain medical conditions such as diabetes, thyroid disease and anemia may also affect fertility.

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European Association of Urology guidelines on male infertility: the 2012 update. Drugs, assisted reproductive technology, and surgery are common treatments. A woman who keeps having miscarriages is also considered infertile.

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Trauma, previous attempts at sperm aspiration, and inguinal surgery may also result in ductal blockage. Eating disorders: If an eating disorder leads to serious weight loss, fertility problems may arise.

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Gracia CR, Sammel MD, Coutifaris C, Guzick DS, Barnhart KT. The seminal vesicles provide 40-80% of the semen volume, which includes fructose for sperm nutrition, prostaglandins and other coagulating substances, and bicarbonate to buffer the acidic vaginal vault. Definition of Infertility Infertility is defined as the inability to conceive after 12 months of having sexual intercourse with average frequency, without the use of any form of birth control. Fertility may improve after adopting a gluten-free diet.Infertility can be caused by many different things. As a woman gets older, the number of her eggs decreases rapidly. Idiopathic hypogonadotropic hypogonadism A failure of GnRH secretion without any discernible underlying cause may be observed alone (isolated) or as part of Kallmann syndrome, which is associated with midline defects such as anosmia, cleft lip and cleft palate, deafness, cryptorchidism, and color blindness. Vasoepididymostomy to the Head of the Epididymis: Recovery of Normal Spermatozoal Motility. (PDF, 3 MB)Fertility and Sterility, 1980. In one study,  treatment with recombinant HBD1 in asthenozoospermic and leukocytospermic patients who were deficient in HBD1 resulted in improved bactericidal activity and sperm quality, which supports this protein’s role in fertility and its potential role in managing infertility.[28] Other causes Causes of testicular failure also include the following: Granulomatous disease – Leprosy and sarcoidosis may infiltrate the testicle Sickle cell disease – Sickling of cells within the testis leads to microinfarcts Excessive use of alcohol, cigarettes, caffeine, or marijuana Despite a thorough workup, nearly 25% of men have no discernible cause for their infertility. A small incision is made in the abdomen, and a thin, flexible microscope with a light at the end, called a laparoscope, is inserted through it.