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Sterility is the inability to conceive and infertility is the inability to complete a full term pregnancy and give birth to a healthy child. Women attempting pregnancy at age 40 or older have a 50% decreased fertility rate and a two-fold to three-fold increased risk of spontaneous abortion compared with younger women. Reversal of Vasectomy and the Treatment of Male Infertility. (PDF, 4 MB) Urologic Clinics of North America, 1981.

Histologic endometrial dating is not considered reliable nor is it predictive of fertility. Hjollund NH, Storgaard L, Ernst E, Bonde JP, Olsen J.

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Microscopic Vasovasostomy and Spermatogenesis. (PDF, 1 MB) The Journal of Urology, 1977. Gonadotrophins for idiopathic male factor subfertility. If he has two X chromosomes and one Y chromosome, as in Klinefelter's syndrome, the testicles will develop abnormally and there will be low testosterone and a low sperm count or no sperm. Histologic endometrial dating is not considered reliable nor is it predictive of fertility.

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In patients with nonobstructive azoospermia, retrograde ejaculation can be the etiologic factor. [107] The treatment consists of recovering sperm from a urine sample collected immediately after ejaculation. This applies to the ability to conceive with her eggs, but not with donor eggs. At least one open tube is required for IUI, and any sperm abnormality cannot be severe, otherwise the sperm will not be able to swim to and fertilize the egg.

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If the sperm do not have the right shape, or they cannot travel rapidly and accurately towards the egg, conception may be difficult. IUI increases the number of the sperm in the fallopian tubes, where fertilization takes place. Excess alcohol consumption: This may lower male fertility. Spermatid Conception. (PDF, 1 MB) Human Reproduction, 1998. Electric or vibratory stimulation to achieve ejaculation: Ejaculation is achieved with electric or vibratory stimulation. 40 Patients using these agents should be counseled about these risks. However, about one in five cases of infertility has no clear diagnosed cause.[73] In Britain, male factor infertility accounts for 25% of infertile couples, while 25% remain unexplained. Over the past three decades, huge advancements in fertility science have helped millions of couples to overcome their difficulties and have children of their own. In patients with varicocele, there is insufficient evidence to suggest corrective surgery will increase live birth rates, despite improvement in semen analysis results. Bromocriptine and cabergoline are dopamine agonists used to suppress prolactin levels. The pituitary gland controls most other hormonal glands in the human body. Sperm can survive inside the female for up to 5 days, while an egg can be fertilized for up to 1 day after ovulation. Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1.