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The interstitium between the seminiferous tubules contains the Leydig cells, fibroblasts, lymphatics, blood vessels, and macrophages. Estimating the prevalence of infertility in Canada [published correction appears in Hum Reprod. Hysterosalpingography: Fluid is injected into the woman's uterus and X-rays are taken to determine whether the fluid travels properly out of the uterus and into the fallopian tubes. Diverse Spermatogenic Defects in Humans Caused by Y Chromosome Deletions Encompassing a Novel RNA-binding Protein Gene. (PDF, 2 MB) Human Reproduction, 1996.

Female factor Dysfunction of the female reproductive organs is also apparent in around 40% of infertile couples. Vascular injuries can result in hemorrhage that may be life-threatening. In another 30% of all cases, the cause is in the male partner.

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Coital frequency is positively correlated with pregnancy rates. The secondary spermatocytes undergo a second meiosis and become spermatids. Intracytoplasmic Sperm Injection and Infertility. (PDF, 53 KB) Nature Genetics, 2001.

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An ultrasound scan can detect an ectopic pregnancy. The AZFc Region of the Y Chromosome Features Massive Palindromes and Uniform Recurrent Deletions in Infertile Men. (PDF, 5 MB) Nature Genetics, 2001. Sulfasalazine: This anti-inflammatory drug can significantly lower a man's sperm count.

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There is more controversy regarding intramural fibroids, where larger ones may have an impact and may necessitate removal. IVF in action Intracytoplasmic sperm injection (ICSI): A single sperm is injected into an egg to achieve fertilization during an IVF procedure. In cases of poor sperm quality, intrauterine insemination can be performed. Intrauterine insemination (IUI): At the time of ovulation, a fine catheter is inserted through the cervix into the uterus to place a sperm sample directly into the uterus. Some respond by actively avoiding the issue altogether; middle-class men are the most likely to respond in this way.[21] In the United States some treatments for infertility, including diagnostic tests, surgery and therapy for depression, can qualify one for Family and Medical Leave Act leave. An estimated 34 million women, predominantly from developing countries, have infertility which resulted from maternal sepsis and unsafe abortion (long term maternal morbidity resulting in a disability). Alcohol: Any amount of alcohol consumption can affect the chances of conceiving.