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If natural selection is the primary error correction mechanism that prevents random mutations on the Y chromosome, then fertility treatments for men with abnormal sperm (in particular ICSI) only defer the underlying problem to the next male generation. Studies on Testicular Biopsies from Vasectomized Men. (PDF, 18 MB) Chapter 21 from Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man, 1979. Outside pregnancy and lactation, women with high levels of prolactin may have irregular ovulation cycles and fertility problems. Release of GnRH is stimulated by melatonin from the pineal gland and inhibited by testosterone, inhibin, corticotropin-releasing hormone, opiates, illness, and stress. In 10% of cases, alterations in the chemical signals from the hypothalamus can easily seriously affect the ovaries. Ultrastructure of Human Sperm in Men with Congenital Absence of the Vas Deferens: Clinical Implications. (PDF, 2 MB) Fertility and Sterility, 1992.

Debate: Are Spermatid Injections of any Clinical Value? (PDF, 6 MB) Human Reproduction, 1998. Luttjeboer F, Harada T, Hughes E, Johnson N, Lilford R, Mol BW.

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Mannitol Induced Central Nervous System Toxicity in Renal Failure. (PDF, 4 MB) Investigative Urology, 1972. Requirements for Female Fertility One of the requirements for female fertility is a functioning reproductive anatomy and physiology.

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Silent Sorority: A Barren Woman Gets Busy, Angry, Lost and Found.I was 26 years old when I was first diagnosed with infertility. Find out more about fertility tests and how problems are diagnosed.Gonadal and sexual functions are mediated by the hypothalamic-pituitary-gonadal axis, a closed-loop system with feedback control from the testicles. Effect of metformin on ovulation and reproductive outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials. The sperm moves up the cervix, towards the uterus, and into the fallopian tubes to reach and fertilize the egg. Seminoma Discovered in Two Males Undergoing Successful Testicular Sperm Extraction for Intracytoplasmic Sperm Injection. (PDF, 807 KB) Human Reproduction, 1995.

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Prolactin stimulates milk production during breastfeeding. Bromocriptine and cabergoline are dopamine agonists used to suppress prolactin levels. Infectious, anatomic, metabolic, and functional problems associated with infertility are seen less frequently. (Also see Infertility.) The only confirmed infectious cause of infertility in the bitch is brucellosis (see Brucellosis in Dogs). Retrograde ejaculation: Sperm can be taken directly from the bladder and injected into an egg in the laboratory. Some causes are more common in some countries than others, such as pelvic inflammatory diseases (PID) and sexually transmitted infections (STI) in Africa [10]. The Treatment of Azoospermia with Surgery and ICSI. (PDF, 4 MB) Chapter 10 from Male Fertility & Infertility, 1998. Gonadotropin release is modulated by various other signals, such as estradiol (a potent inhibitor of both LH and FSH release), and inhibin from the Sertoli cell, which causes a selective decrease in FSH release. Blood, urine, and imaging tests can be done to discover why you are having trouble getting pregnant. Disadvantages of IVF include failure to conceive, OHSS and expensiveness.