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The normal working of the male reproductive system involves first the production of sufficient numbers of functional sperm cells and then the delivery of these sperm to the ejaculate. If they're damaged, it can seriously affect the quality of your semen. For patients wishing to conceive, the medical approach is not indicated, as it delays treatment for infertility.

Hypogonadotropic Hypopituitarism: Low pituitary gland output of LH and FSH.  This condition arrests sperm development and causes the progressive loss of germ cells from the testes and causes the seminiferous tubules and Leydig (testosterone producing) cells to deteriorate.  May be treated with the drug Serophene.  However, if all germ cells are destroyed before treatment commences, the male may be permanently infertile. Normal Intrauterine Pregnancy After Reversal of Tubal Sterilization in the Wife and Vasectomy in the Husband.(PDF, 1 MB) Fertility and Sterility, 1978. ART: Intracytoplasmic Sperm Injection (ICSI) Another ART procedure  Intracytoplasmic Sperm Injection (ICSI)  involves the injection of a single sperm into the egg.

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Diagnosis and Management of Hypogonadism, Infertility, and Impotence. (PDF, 13 MB) Chapter 22 of textbook,Male Reproductive Dysfunction, 1986. Treatment of tubal obstruction generally requires referral for subspecialty care. Some causes, such as hyperprolactinemia, are reversible with proper treatment. Programming of Ovarian Stimulation with Norethindrone Acetate in IVF/GIFT Cycles. (PDF, 2 MB) Human Reproduction, 1989.

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Especially in men, psychological explanations should be considered as they are frequently the cause of sexual dysfunctions. Adhesions with the surrounding tissue can develop as well, and reduce the motility of the tubes.

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Adverse effects of metformin include GI intolerance, nausea, vomiting, and abdominal cramps. 7 million women reported impaired ability to get pregnant or carry a baby to term. Combined infertility[edit] In some cases, both the man and woman may be infertile or sub-fertile, and the couple's infertility arises from the combination of these conditions. The maximum recommended dosage is 150 mg/day for 5 days. Seventy-five percent of patients have testicular atrophy and primary testicular failure due to degeneration of the seminiferous tubules. For women aged 35, about 94% who have regular unprotected sexual intercourse get pregnant after three years of trying. Partners may become more anxious to conceive, increasing sexual dysfunction.[17] Marital discord often develops, especially when they are under pressure to make medical decisions. Stem cell therapy[edit] Nowadays, there are several treatments (still in experimentation) related with stem cell therapy. Women with anovulation may be treated in the primary care setting with clomiphene to induce ovulation. It makes the pituitary gland release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH).