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Any of the following can cause a man to have a low sperm count or abnormal sperm: Varicocele — an abnormal collection of bulging veins above the testicle; they’re the most common cause of correctable male infertility, accounting for 38% of cases Undescended testicle Infections in the testicle (orchitis), the prostate (prostatitis), or elsewhere in the body that causes a fever Chemotherapy for cancer Medicines such as anabolic steroids or anti-seizure medicines Genetic abnormalities Hormone problems In some cases, these problems can be reversed, but other times they can’t. In one study,  treatment with recombinant HBD1 in asthenozoospermic and leukocytospermic patients who were deficient in HBD1 resulted in improved bactericidal activity and sperm quality, which supports this protein’s role in fertility and its potential role in managing infertility.[28] Other causes Causes of testicular failure also include the following: Granulomatous disease – Leprosy and sarcoidosis may infiltrate the testicle Sickle cell disease – Sickling of cells within the testis leads to microinfarcts Excessive use of alcohol, cigarettes, caffeine, or marijuana Despite a thorough workup, nearly 25% of men have no discernible cause for their infertility. Causes of Male Infertility Male infertility may be a result of some conditions that affect the quality of sperm, lead to low sperm production (oligospermia), or lead to the absence of sperm production (azoospermia). Intra-uterine insemination for male subfertility.

A high serum estradiol level (greater than 60 to 80 pg per mL [220 to 294 pmol per L]) in conjunction with a normal FSH level has also been associated with lower pregnancy rates. In my case, the inability to conceive was the result of a condition called stage 4 endometriosis.

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The vas deferens carries sperm from the epididymis to the ejaculatory duct and the urethra. High cortisol levels may also be seen with exogenous steroid use, such as that administered to patients with ulcerative colitis, asthma, arthritis, or organ transplant.

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Causes of Female Infertility The following causes may lead to infertility in women: Pelvic inflammatory disease, which can lead to blocked or damaged fallopian tubes. Modifying these behaviors can improve a man�s fertility and should be considered when a couple is trying to achieve pregnancy. Endometrial polyps Endometrial polyps are growths found in the uterine cavity.

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0.[44] Environmental factors Toxins such as glues, volatile organic solvents or silicones, physical agents, chemical dusts, and pesticides.[45][46] Tobacco smokers are 60% more likely to be infertile than non-smokers.[47] German scientists have reported that a virus called adeno-associated virus might have a role in male infertility,[48] though it is otherwise not harmful.[49] Other diseases such as chlamydia, and gonorrhea can also cause infertility, due to internal scarring (fallopian tube obstruction).[50][51][52] Alimentary habits[53] Obesity: The obesity epidemic has recently become is a serious issue, particularly in industrialized nations. Common causes of infertility of females include: ovulation problems (e.g. polycystic ovarian syndrome, PCOS, the leading reason why women present to fertility clinics due to anovulatory infertility.[58]) tubal blockage pelvic inflammatory disease caused by infections like tuberculosis age-related factors uterine problems previous tubal ligation endometriosis advanced maternal age immune infertility Males[edit] The main cause of male infertility is low semen quality. Serum LH determination is more precise, especially when performed in combination with pelvic ultrasonography. ICSI with Epididymal and Testicular Sperm Retrieval. (PDF, 1 MB) Male Sterility and Motility Disorders: Etiological Factors and Treatment, 1998. Specialized semen analysis, including genetic testing of the sperm (looking for the presence of antibodies) and evaluation of immobile sperm (to see if they are dead or alive). The HSG is usually scheduled between days 6 and 13 of the cycle - after bleeding and before ovulation. Only 5-10% of these couples eventually achieve a pregnancy within 5 years. 40 Patients using these agents should be counseled about these risks. Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988–1989). Women in group II include those with polycystic ovary syndrome and hyperprolactinemia.