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Hypogonadotropic Hypopituitarism: Low pituitary gland output of LH and FSH.  This condition arrests sperm development and causes the progressive loss of germ cells from the testes and causes the seminiferous tubules and Leydig (testosterone producing) cells to deteriorate.  May be treated with the drug Serophene.  However, if all germ cells are destroyed before treatment commences, the male may be permanently infertile. In patients with varicocele, there is insufficient evidence to suggest corrective surgery will increase live birth rates, despite improvement in semen analysis results. 8 A high serum FSH level (greater than 30 to 40 mIU per mL [30 to 40 IU per L]) with a low estradiol level can distinguish ovarian failure from hypothalamic pituitary failure, which typically reveals a low or normal FSH level (less than 10 mIU per mL [10 IU per L]) and a low estradiol level.

Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics. Exposure to chemicals: Pesticides, for example, may increase the risk.

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Chemotherapy: Some chemotherapy drugs can result in ovarian failure. Here, the hormones FSH (= follicle stimulating hormone) and LH (= luteinizing hormone) play an important role. Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Regression of Metastases after Nephrectomy for Renal Cell Carcinoma. (PDF, 1 MB) British Journal of Urology, 1975.

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Examples of such health issues include infections, endometriosis, and fibroids. Quantitative Analysis of Testicle Biopsy: Determination of Partial Obstruction and Prediction of Sperm Count after Surgery for Obstruction. (PDF, 4 MB) Fertility and Sterility, 1981. The medicalization of infertility has unwittingly led to a disregard for the emotional responses that couples experience, which include distress, loss of control, stigmatization, and a disruption in the developmental trajectory of adulthood.[16] Infertility may have psychological effects.

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Generally, evaluation should be offered to couples who have not conceived after one year of unprotected vaginal intercourse. Therefore, pelvic ultrasonography is required before CC is initiated. [207] Pure FSH treatment for ovulation induction is another alternative for patients with PCOS who are clomiphene resistant. The procedure is performed in an outpatient setting in the vast majority of cases, and recovery time can be as little as a few days. Testing may begin with a physical exam and questions about past medical problems. Effect of male age on fertility: evidence for the decline in male fertility with increasing age. Infertility might contribute to stress, anxiety, and depression in couples trying to conceive, and treatment can be medically invasive and expensive.