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In some women, and especially with age, the membrane becomes harder. 549 KB Effect of Age on Male Fertility. (PDF, 5 MB) Chapter from textbook, Seminars in Reproductive Endocrinology, 1991. A Modern Approach to Male Infertility. (PDF, 2 MB) Serono Symposia, Insights Into Infertility Newsletter, 1997. Web of Science, in-addition to the relevant printed medical journals and periodicals.

Assisted hatching: The embryologist opens a small hole in the outer membrane of the embryo, known as the zona pellucid. If the E2 and FSH levels are in the normal range, clomiphene citrate is the drug of choice, as previously described. Cervical mucus problems impairing conception may be treated with intrauterine insemination (IUI) or uterine instillation of specially prepared sperm.

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Females[edit] The following causes of infertility may only be found in females. With this treatment, the patient experience spermatogenesis, and therefore, it has the chance to have offspring if he wants to. Patients who do not achieve ovulation after three to six cycles should be referred to an infertility specialist for further treatment. Low sperm mobility (motility): The sperm cannot "swim" as well as they should to reach the egg. Ejaculation disorders Ejaculation disorders include premature ejaculation, anejaculation (the failure to ejaculate), and retrograde ejaculation, which is when semen enters the bladder during orgasm instead of coming out the tip of the penis. Debate: Are Spermatid Injections of any Clinical Value? (PDF, 6 MB) Human Reproduction, 1998.

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In addition to the alteration of menstrual periods and infertility, chronic anovulation can cause or exacerbate other long term problems, such as hyperandrogenism or osteopenia. Testosterone is secreted in a diurnal pattern, peaking a few hours after the man awakens from sleep. Exposure to chemicals: Pesticides, for example, may increase the risk.

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National Collaborating Centre for Women's and Children's Health. Effect of metformin on ovulation and reproductive outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials. Laboratory studies have suggested that long-term acetaminophen use during pregnancy may affect fertility in males by lowering testosterone production. This technique involves an injection of a single healthy sperm directly injected into mature egg. License: Public Domain Due to increased levels of prolactin, the pulsatile release of GnRH is inhibited. Chemotherapy: Some types may significantly reduce sperm count.