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In humans, infertility is the inability to become pregnant after one year of intercourse without contraception involving a male and female partner.[2] There are many causes of infertility, including some that medical intervention can treat.[3] Estimates from 1997 suggest that worldwide about five percent of all heterosexual couples have an unresolved problem with infertility. Refinements in the Methodology of Injection for Transvaginal Gamete Intra-Fallopian Transfer. (PDF, 2 MB) Human Reproduction, 1994. There may be testicular malformations, hormone imbalance, or blockage of the man's duct system.

The cause of sterility can also be found in the tubes. In this case, your doctor may recommend advanced fertility treatment — assisted reproductive technologies (ART) treatment.

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WHAT'S THE DIFFERENCE BETWEEN PRIMARY AND SECONDARY STERILITY? Ectopic pregnancy This is when a fertilized egg implants outside the womb, usually in a fallopian tube.

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The problem is getting the sperm where they need to go. The following is a list of hormonal disorders which can disrupt male infertility: Hyperprolactinemia: Elevated prolactin--a hormone associated with nursing mothers, is found in 10 to 40 percent of infertile males.  Mild elevation of prolactin levels produces no symptoms, but greater elevations of the hormone reduces sperm production, reduces libido and may cause impotence.  This condition responds well to the drug Parlodel (bromocriptine). Radiation therapy: This can impair sperm production. It is more successful in women who have previously been pregnant.

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Clinical diagnostic testing for the cytogenetic and molecular causes of male infertility: the Mayo Clinic experience. It is often prescribed for Crohn's disease or rheumatoid arthritis. If there's a problem with the mucus, it can make it harder to conceive. As the major causes of infertility are sperm abnormalities, ovulation dysfunction, and fallopian tube obstruction, the preliminary adviced investigations for the infertile couple should be focused on semen analysis (to be compared with the WHO reference values [27]), detection of ovarian function by hormonal assay (early follicular FSH and LH levels, and mid-luteal progesterone), and evaluation of tubal patency by hysterosalpingography (HSG) [17-32], (Appendix 3). Compensatory and Obligatory Renal Growth in Rats. (PDF, 1 MB) American Journal of Physiology, 1974. Especially in men, psychological explanations should be considered as they are frequently the cause of sexual dysfunctions.