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With this condition, boys are born with a different chromosomal make-up, generating an absence of spermatozoa production or minimum generation of sperm that ceases at an early age. Causes of infertility include male factors, ovulatory dysfunction, uterine abnormalities, tubal obstruction, peritoneal factors, or cervical factors.

A paper published in JAVMA (Journal of the American Veterinary Medical Association) in 2005 showed that dogs spayed laparoscopically experienced significantly less pain (65%) than those that were spayed with traditional "open" methods.[8] Arthroscopy, thoracoscopy, cystoscopy are all performed in veterinary medicine today. Dr Barbieri of Harvard Medical School has indicated that cases of anovulation are quite frequent in women with a BMI (body mass index) over 27 kg/m2.[6][7][8] Unfortunately, not only does excess weight have a negative impact on ovulation itself,[9] but also on treatment efficacy and outcomes of ART (assisted reproductive technique).[10][11] Diagnosis[edit] Fertility awareness and LH measurement[edit] Symptoms-based methods of fertility awareness may be used to detect ovulation or to determine that cycles are anovulatory. Infertility may be caused by blockage of the Fallopian tube due to malformations, infections such as chlamydia or scar tissue. This process has revolutionized assisted reproductive technology and the way reproductive endocrinologists can help people in having a baby. This sterile needle is attached to sterile suction tubing and a collecting vial.

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The presence of open tubes is essential for natural conception, as sperm must traverse the tubes in order to reach and fertilize the ovulated egg. Some suggest that the number of times a couple has intercourse should be reduced to increase sperm supply, but this is unlikely to make a difference. Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1. An abnormal semen analysis warrants a further evaluation usually by a reproductive urologist.

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Many cases are treated with medication or may require surgical procedures. Debate: Are Spermatid Injections of any Clinical Value? (PDF, 6 MB) Human Reproduction, 1998. After 3-6 hours, the sperm is added to the oocytes. Recombination Between Palindromes P5 and P1 on the HUman Y Chromosome Causes Massive Deletions and Spermatogenic Failure. (PDF, 786 KB) The American Journal of Human Genetics, 2002. Bladder neck closure during ejaculation is vital to ensure antegrade ejaculation. Assisted conception The following methods are currently available for assisted conception.

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If the sperm are of good quality and the mechanics of the woman's reproductive structures are good (patent fallopian tubes, no adhesions or scarring), a course of ovulation induction maybe used. These specimens benefit most from layering a washed pellet of sperm with nutrient media and allowing the motile fraction to swim up into the media before being separated. [109] After sperm preparation, the spermatozoa are enhanced in motility and become activated and ready to fertilize an oocyte. Transplantation of a Human Testis for Anorchia. (PDF, 19 MB) Fertility and Sterility, 1978. 21,22 Evaluation of Women Jump to section + The etiology of female infertility can be broken down into ovulation disorders, uterine abnormalities, tubal obstruction, and peritoneal factors. A luteal phase defect results in low production of the hormone progesterone, which is necessary for maintaining a pregnancy. Female factor Dysfunction of the female reproductive organs is also apparent in around 40% of infertile couples. Septate uterus The hypothesis that a uterine septum can cause infertility is controversial. The testicular-epididymal component includes sperm and comprises about 5% of the ejaculate volume.