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Some causes are more common in some countries than others, such as pelvic inflammatory diseases (PID) and sexually transmitted infections (STI) in Africa [10]. NIH: National Institute of Child Health and Human Development Start Here Defining Infertility (American Society for Reproductive Medicine) - PDF Infertility (Mayo Foundation for Medical Education and Research) Also in Spanish Infertility and Fertility (National Institute of Child Health and Human Development) Infertility FAQ's (Centers for Disease Control and Prevention) Optimizing Natural Fertility (American Society for Reproductive Medicine) - PDF Also in Spanish Pregnancy Problems? The rising number of obese individuals may be due in part to an energy-rich diet as well as insufficient physical exercise.  In addition to other potential health risks, obesity can have a significant impact on male and female fertility. Delayed conception and active and passive smoking. Apparent Fertility of Human Spermatozoa from the Caput Epididymidis. (PDF, 4 MB) Journal of Andrology, 1989. Spermatid Conception. (PDF, 1 MB) Human Reproduction, 1998.

The sperm moves up the cervix, towards the uterus, and into the fallopian tubes to reach and fertilize the egg. Testis Biopsy and the Infertile Male. (PDF, 20 MB) Chapter 15 from textbook Office Andrology, 2005.

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There are three types of fibroids: 1) subserosal, or fibroids that extend more than 50% outside of the uterus; 2) intramural, where the majority of the fibroid is within the muscle of the uterus without any indentation of the uterine cavity; and 3) submucosal, or fibroids the project into the uterine cavity. Consequently, amenorrhea, an anovulatory cycle, and corpus luteum deficiency can develop. Round Spermatid Injection. (PDF, 422 KB) Fertility and Sterility, 2000. Bushnik T, Cook JL, Yuzpe AA, Tough S, Collins J. Transplantation of a Human Testis for Anorchia. (PDF, 19 MB) Fertility and Sterility, 1978.

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6) Male factors affecting sperm function: Male factor infertility has been associated as a contributing factor causing infertility in 40-50% percent of cases, and as the sole cause for infertility in 15-20% percent of cases. No Differences in Outcome after Intracytoplasmic Sperm Injection with Fresh or with Frozen-thawed Epididymal Spermatozoa. (PDF, 66 KB) Human Reproduction, 1999. Those with a varicocele diagnosable only on scrotal ultrasonography have subclinical varicoceles and will likely not benefit from repair. Gonadotrophins for idiopathic male factor subfertility. Radiation therapy: If this is aimed near the reproductive organs, it can increase the risk of fertility problems.

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In patients with varicocele, there is insufficient evidence to suggest corrective surgery will increase live birth rates, despite improvement in semen analysis results. Effects[edit] Psychological[edit] The consequences of infertility are manifold and can include societal repercussions and personal suffering. In other cases, the cause is suspected to be immunological or genetic; it may be that each partner is independently fertile but the couple cannot conceive together without assistance. Growth of Baby Kidneys Transplanted into Adults. (PDF, 1 MB) Archives of Surgery, 1976. Techniques for the Resolution of Testicular Obstruction. (PDF, 8 MB) Chapter 78 from textbook, Reconstructive Urology, 1992. Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1. Polycystic ovarian syndrome is the most frequent indication for ovulation induction.