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It has been suggested that infertility be classified as a form of disability.[22] Causes[edit] Immune infertility[edit] Antisperm antibodies (ASA) have been considered as infertility cause in around 10–30% of infertile couples.[23] In both men and women, ASA production are directed against surface antigens on sperm, which can interfere with sperm motility and transport through the female reproductive tract, inhibiting capacitation and acrosome reaction, impaired fertilization, influence on the implantation process, and impaired growth and development of the embryo. The bladder must be emptied 1 hour prior to sperm collection, and a second dose of sodium bicarbonate is taken along with 16 ounces of fluid. Most typical are decreased libido, erectile dysfunction, orgasmic dysfunction, and ejaculatory dysfunction.

A routine part of the initial evaluation is testing of specific serum hormone levels, which usually includes FSH, LH, testosterone, and prolactin. The Three-kidney Rat Model. (PDF, 2 MB) Investigative Urology, 1974. Taking testosterone, or any over-the-counter androgen like DHEA (for weight training), can harm fertility, says Shaban. “People have had unnecessary surgeries because they forgot to say they were on these medicines,” he warns. A variety of disorders ranging from hormonal disturbances to physical problems, to psychological problems can cause male infertility.  Although many treatment options are now available, in many cases treatment will not work.  In many instances, male infertility is caused by testicular damage resulting in an inability of the testicle to produce sperm.  Once damaged, the testicle will not usually regain its sperm-making capabilities; this aspect of male infertility is analogous to menopause (though not natural like menopause) for women and cannot usually be treated.  Despite medicine�s limited ability to treat male infertility, many successful treatment options are available for its many causes.  Besides testicular damage, the main causes of male infertility are low sperm production and poor sperm quality.   The Causes of Male Infertility Male infertility has many causes--from hormonal imbalances, to physical problems, to psychological and/or behavioral problems.  Moreover, fertility reflects a man�s �overall� health.  Men who live a healthy lifestyle are more likely to produce healthy sperm.  The following list highlights some lifestyle choices that negatively impact male fertility--it is not all-inclusive: · Smoking--significantly decreases both sperm count and sperm cell motility. · Prolonged use of marijuana and other recreational drugs. · Chronic alcohol abuse. · Anabolic steroid use--causes testicular shrinkage and infertility. · Overly intense exercise--produces high levels of adrenal steroid hormones which cause a    testosterone deficiency resulting in infertility. · Inadequate vitamin C and Zinc in the diet. · Tight underwear--increases scrotal temperature which results in decreased sperm production. · Exposure to environmental hazards and toxins such as pesticides, lead, paint, radiation, radioactive   substances, mercury,  benzene, boron, and heavy metals · Malnutrition and anemia. · Excessive stress!

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About 10% of reproductive age women are affected by endometriosis. Around one third of couples have difficulty conceiving due to a low sperm count.

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Submucosal fibroids: Benign or non-cancerous tumors occur in the muscular wall of the uterus. Females[edit] The following causes of infertility may only be found in females. The Treatment of Azoospermia with Surgery and ICSI. (PDF, 4 MB) Chapter 10 from Male Fertility & Infertility, 1998. It has been proven useful in overcoming infertility conditions, such as blocked or damaged tubes, endometriosis, repeated IUI failure, unexplained infertility, poor ovarian reserve, poor or even nil sperm count. Patients should undergo an MRI or CT scan of the sella turcica for diagnostic purposes to determine whether a microprolactinoma or a macroprolactinoma is present.

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Clean, Intermittent Self-catheterization in the Treatment of Urinary Tract Disease. (PDF, 2 MB) The Journal of Urology, 1972. Chemotherapy: Some chemotherapy drugs can result in ovarian failure. In a recent meta-analysis, letrozole was found to be as effective as other methods of ovulation induction. [169] The usual dose for letrozole ovulation induction is 2. In many cases, cornual obstruction diagnosed on HSG represents simple cornual spasm. The pituitary gland is controlled by the hypothalamus. Some diseases: Conditions that are sometimes linked to lower fertility in males are anemia, Cushing's syndrome, diabetes, and thyroid disease. Transmission of Male Infertility to Future Generations: Lessons from the Y Chromosome. (PDF, 303 KB) Human Reproduction Update, 2002. Metformin (Glucophage) is another type of medication that may help you ovulate normally if you have insulin resistance or PCOS (polycystic ovarian syndrome). It makes the pituitary gland release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Existing definitions of infertility lack uniformity, rendering comparisons in prevalence between countries or over time problematic. The maximum recommended dosage is 150 mg/day for 5 days. Although many of these can be treated through surgery or hormonal substitutions, some may be indefinite.[59] Infertility associated with viable, but immotile sperm may be caused by primary ciliary dyskinesia. Endometriosis may be treated through laparoscopic surgery. Large submucosal uterine fibroids may make the uterus' cavity bigger, increasing the distance the sperm has to travel. Most surgical treatment for endometriosis is currently performed through operative laparoscopy. [145, 146, 147] Laparotomy has been relegated to the treatment of severe disease or if a need for hysterectomy arises. [145] Medical treatment Medical treatment is directed toward suppressing estrogen production by the ovary. This combination of laboratory test results may indicate ovarian insufficiency or diminished ovarian reserve.