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Genetic Causes of Female Infertility

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After recovery, the testicle may return to normal or may atrophy. Human chorionic gonadotropin (Ovidrel, Pregnyl): Used together with clomiphene, hMG, and FSH, this can stimulate the follicle to ovulate.

Ovarian hyperstimulation syndrome The ovaries can swell, leak excess fluid into the body, and produce too many follicles, the small fluid sacs in which an egg develops. Instruments can be introduced through the hysteroscope, allowing the surgeon to remove or correct any anatomic abnormalities. A specimen is collected by masturbation into a clean, dry, sterile container or during coitus using special condoms (containing no spermicidal lubricants).

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Genetic Causes of Female Infertility

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Determination of serum E2 and LH levels can also be performed. [203] Treatment of Primary Amenorrhea hMG is the treatment of choice for patients with primary amenorrhea due to hypopituitarism. Effects[edit] Psychological[edit] The consequences of infertility are manifold and can include societal repercussions and personal suffering. Varicoceles are repaired with surgery to block off the abnormal veins.

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Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1. Effect of male age on fertility: evidence for the decline in male fertility with increasing age. Sexually transmitted infections (STIs): Chlamydia can damage the fallopian tubes in a woman and cause inflammation in a man's scrotum. A review of systems and physical examination of the endocrine and gynecologic systems should be performed.

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Gonadotropin release is modulated by various other signals, such as estradiol (a potent inhibitor of both LH and FSH release), and inhibin from the Sertoli cell, which causes a selective decrease in FSH release. Intrauterine insemination. For this procedure, after semen gets rinsed with a special solution, a doctor places it into your uterus when you're ovulating. Demographic definitions of infertility An inability of those of reproductive age (15-49 years) to become or remain pregnant within five years of exposure to pregnancy. (DHS2) An inability to become pregnant with a live birth, within five years of exposure based upon a consistent union status, lack of contraceptive use, non-lactating and maintaining a desire for a child. (Trends in prevalence4). Placenta Percreta Invading Bladder. (PDF, 2 MB) The Journal of Urology, 1973. If conservative medical treatments fail to achieve a full term pregnancy, the physician or WHNP may suggest the patient undergo in vitro fertilization (IVF). Causes include: Surgery: Pelvic surgery can sometimes cause scarring or damage to the fallopian tubes. The evaluation of the azoospermic male: AUA best practice statement. Additionally, there is concern that the stress of a strict schedule for intercourse may lead to reduced frequency of intercourse. When used in the early follicular phase, letrozole inhibits estrogen synthesis, thereby causing enhanced GnRH pulsatility and consequent FSH and inhibin stimulation. However, medical treatment can be used to reduce the myoma size prior to removal.


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